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KMID : 0370220120560050293
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Yakhak Hoeji
2012 Volume.56 No. 5 p.293 ~ p.298
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Effect of Lignan Components from Schizandra chinensis on Beta-amyloid Aggregation Inhibition and Dissociation
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Yu Ho-JIn
Yoon Mi-So
Kim Do-Yoon
Won Kyung-Jong
Kim Bo-Kyung
Jang Sang-Hee
Lee Hwan-Myung
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Abstract
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The present study tested the effect of Schizandra chinensis lignan compounds, Gomisin A and Schizandrin, on the aggregation and dissociation of beta-amyloid (Aβ)_1-42 to explore a possible therapeutic target for Alzheimer’s disease. Gomisin A significantly inhibited the Aβ_1-42 aggregation in a dose dependent manner, but did not induced the dissociation of aggregated Aβ}_1-42. On the other hand, Schizandrin significantly suppressed the aggregation and dissociation of Aβ_1-42. These results suggest that Gomisin A and Schizandrin, which are known as biologically active ingredients from Schizandra chinensis, may be potentially useful target molecules to develop a drug for the prevention or treatment of Alzheimer’s disease.
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KEYWORD
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Schizandra chinensis, Alzheimer’s disease, beta-amyloid, Schizandrin, Gomisin
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